Toxic multinodular goitre Classification and external resources
ICD-10	E05.2
ICD-9	242.3
DiseasesDB	13184
MedlinePlus	000317
eMedicine	med/920

Toxic multinodular goitre (also known as toxic nodular goitre, toxic nodular struma) is a form of hyperthyroidism - where there is excess production of thyroid hormones. It is characterized by functionally autonomous nodules. It emerges insidiously from nontoxic multinodular goitre.

It is the second most common cause of hyperthyroidism after Graves disease.

Contents 1 Symptoms 2 Related eponym 3 Footnotes 4 External links

Symptoms

Symptoms of toxic multinodular goitre are similar to that of hyperthyroidism, including:

• heat intolerance
• muscle weakness/wasting
• hyperkinesis
• tremor
• irritability
• weight loss
• osteoporosis
• increased appetite
• goitre (swelling of the thyroid gland)
• tachycardia (high heart rate - above 180 bpm at rest)

Related eponym

Plummer's disease is named after an American physician Henry Stanley Plummer but refers to a single toxic nodule (adenoma) which may present with the background of a suppressed multinodular goitre.¹

Footnotes

1. ^ Plummer's disease eponymously named after Henry Stanley Plummer at Who Named It

External links

• Photo of patient
• Photo of goitre

v • d • e Endocrine pathology: endocrine diseases (E00-35, 240-259) Pancreas/ glucose metabolism Diabetes mellitus types: (type 1, type 2, MODY), complications: (coma, angiopathy, ketoacidosis, nephropathy, neuropathy, retinopathy, cardiomyopathy) Hypoglycemia · Hyperinsulinism · Zollinger-Ellison syndrome · insulin receptor (Rabson-Mendenhall syndrome) · Insulin resistance Hypothalamic/ pituitary axes Pituitary Hyperpituitarism (Acromegaly, Hyperprolactinaemia, SIADH) Hypopituitarism (Sheehan's syndrome, Kallmann syndrome, Growth hormone deficiency, Diabetes insipidus) Adiposogenital dystrophy · Empty sella syndrome · Pituitary apoplexy · ACTH deficiency Thyroid Hypothyroidism (Iodine deficiency, Cretinism, Congenital hypothyroidism, Goitre, Myxedema) Hyperthyroidism (Graves disease, Toxic multinodular goitre, Teratoma with thyroid tissue or Struma ovarii) Thyroiditis (De Quervain's thyroiditis, Hashimoto's thyroiditis, Riedel's thyroiditis) Euthyroid sick syndrome · Thyroid hormone resistance · Thyroid nodule Parathyroid Hypoparathyroidism (Pseudohypoparathyroidism) · Hyperparathyroidism (Primary, Secondary, Tertiary) Adrenal Adrenocortical hyperfunction: Cushing's syndrome (Nelson's syndrome, Pseudo-Cushing's syndrome) · Hyperaldosteronism (Conn syndrome, Bartter syndrome) · Glucocorticoid remediable aldosteronism CAH (Lipoid, 3β, 11β, 17α, 21α) Adrenal insufficiency (Addison's disease, Waterhouse-Friderichsen syndrome) · Hypoaldosteronism Gonads ovarian (Polycystic ovary syndrome, Premature ovarian failure) testicular (5-alpha-reductase deficiency, 17-beta-hydroxysteroid dehydrogenase deficiency) · Androgen receptor (Androgen insensitivity syndrome) general (Hypogonadism, Delayed puberty, Precocious puberty) Height Gigantism · Dwarfism/Short stature (Laron syndrome, Psychogenic dwarfism) Thymus Abscess of thymus · Thymus hyperplasia Multiple Autoimmune polyendocrine syndrome · Carcinoid syndrome · Multiple endocrine neoplasia (1, 2) · Progeria · Woodhouse-Sakati syndrome see also congenital, neoplasia

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• This page was last modified on 15 December 2008, at 23:27.

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