Sex linkage is the phenotypic expression of an allele that is related to the chromosomal sex of the individual. This mode of inheritance is in contrast to the inheritance of traits on autosomal chromosomes, where both sexes have the same probability of expressing the trait. Since, in humans, there are many more genes on the X than there are on the Y, there are many more X-linked traits than there are Y-linked traits.
In mammals, the female is the homozygous sex, having two X chromosomes (XX), while the male is heterozygous, having one X and one Y chromosome (XY). Genes that are present on the X or Y chromosome are called sex linked genes.
In birds, the opposite is true: the male is the homozygous sex, having two Z chromosomes (ZZ), and the female (hen) is heterozygous, having one Z and one W chromosome (ZW).
Contents |
Linkage overview
X-linked recessive traits are expressed in all heterogametics, but are only expressed in those homogametics that are homozygous for the recessive allele. For example, an X-linked recessive allele in humans causes hemophilia. Hemophilia is much more common in males than females because males are hemizygous - they only have one copy of the gene in question - and therefore express the trait when they inherit one mutant allele. In contrast, a female must inherit two mutant alleles, a less frequent event since the mutant allele is rare in the population. Tsarevich Alexei of Russia was the most famous sufferer of X-linked hemophilia, and his disease may have played an important role in the overthrowing of the imperial regime and may have changed the course of history for millions of people.
The incidence of recessive X-linked phenotypes in females is the square of that in males (squaring a proportion less than one gives an outcome closer to 0 than the original). If 1 in 20 males in a human population are green color blind, then 1 in 400 females in the population are expected to be color blind (1/20)*(1/20).
X-linked traits are maternally inherited from carrier mothers or from affected father. Each son born to a carrier mother has a 50% probability of inheriting the X-chromosome carrying the mutant allele. There are a few Y-linked traits; these are inherited from the father.
In classical genetics, a reciprocal cross is performed to test if a trait is sex-linked.
(A)  |
(B)  |
(C)  |
| Illustration of some X-linked heredity outcomes (A) the affected father have X-linked dominant allele, the mother is homozygous for the recessive allele, only daughters will be affected (B) the affected mother is hemizygous with one copy of the X-linked dominant allele, both daughters and sons will have 50% probability to be affected (C) the hemizygous mother is called "carrier" because she have one copy of the recessive allele, sons will have 50% probability to be affected, 50% of unaffected daughters will, probably, become carriers like their mother [2]. |
Types of links
Diseases well known for their X-linked recessive inheritance are Haemophilia (types A and B), and color blindness.
X-linked recessive
X-linked inherited diseases occur far more frequently in males because they only have one X chromosome. Females must receive a copy of the gene from both parents to have such a recessive disease. However, they will still be carriers if they receive one copy of the gene. Recessive genes on the X chromosome that cause serious diseases are usually passed from female carriers to their ill sons and carrier daughters. This is because males, who always have the disease and are not just carriers, would have to father a daughter to pass on the gene. This is unlikely because severe genetic diseases often cause death in childhood or early adulthood. Even those males who survive childhood are unlikely to father children because a sickly male will be less likely to find a mate. However, if the disease shows up late in life, or is not severe, he will pass the gene to all of his daughters. He can not pass it to his sons because a male receives his X chromosome from his mother. A mother with one copy of the gene has a 50% chance of passing it to her children of both sexes, but her daughters will just be carriers of the gene unless their father has it, too.
X-linked dominant
There are few examples of X-linked dominant diseases; the best known in this category is vitamin D resistant rickets.
Y-linked
- Various failures in the SRY genes
Sex-linked traits in other animals
- Calico or tortoiseshell cats, those which have orange-and-black fur.
- White eyes in Drosophila melanogaster flies, the first sex-linked gene ever discovered.
References
- ^ Thomas Hunt Morgan (1919), The physical basis of heredity. Philadelphia: J.B. Lippincott Company.
- ^ Genetics home reference (2006), Inheriting Genetic Conditions illustrations, National Library of Medicine.
Open source encyclopedia content modification information:
This page was last modified on 27 February 2010 at 06:17.
Authorship and Review
Open source encyclopedia content provided here is not reviewed directly by PediaView.com. Content is authored by an open community of volunteers and is not produced by or in any way affiliated with PediaView.com.
Usage Guidelines
This article is licensed under the GNU Free Documentation License. It uses material from the Wikipedia article on "Sex linkage", which is available in its original form here:
http://en.wikipedia.org/w/index.php?title=Sex_linkage
All Wikipedia text is available under the terms of the GNU Free Documentation License. Wikipedia® itself is a registered trademark of the Wikimedia Foundation, Inc.